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МАКРОЛИДНОЕ ПРОИЗВОДНОЕ, ЗАМЕЩЕННОЕ ПО С-4-ПОЛОЖЕНИЮ
专利权人:
MEJDZI SEJKA FARMA KO.; LTD.
发明人:
SUGIMOTO Tomokhiro,СУГИМОТО Томохиро,SASAMOTO Naoki,САСАМОТО Наоки,KUROSAKA Dzun,КУРОСАКА Дзун,KHAYASI Masato,ХАЯСИ Масато,YAMAMOTO Kanako,ЯМАМОТО Канако,KASIMURA Masato,КАСИМУРА Масато,USIKI YAsunobu
申请号:
RU2013142898/04
公开号:
RU0002599718C2
申请日:
2012.02.20
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I) and pharmaceutically acceptable salts thereofwhere Me denotes a methyl group, R1 is a hydrogen atom, C1-6alkyl group (C1-6alkyl group can be substituted with one substitute selected from hydroxy group, C1-6alkoxy group, diC1-6alkylamino group and group, presented by formula -NR78COR79 or formula -NR80SO2R81, where R78 and R80 represent a hydrogen atom and R79 and R81, which can be identical or different, denote a hydrogen atom or C1-6alkyl group) or C1-6alkylsulphonyl group, R2 represents a hydrogen atom, 4-8-member saturated heterocyclic group with one heteroatom selected from nitrogen atoms (saturated heterocyclic group can be substituted with one substitute selected from phenyl C1-6alkyl group and C1-6alkyl group), C1-6alkanoyl group (C1-6alkanoyl group can be substituted with an amino group or diC1-6alkylamino group) or C1-6alkyl group which can be substituted with 1-3 substitutes selected from a group of substitutes 1, or R1 and R2 may be combined together with a nitrogen atom to which they are bonded to form a 4-8-member saturated nitrogen-containing heterocyclic group, which can additionally contain 1 heteroatom selected from a nitrogen atom (saturated nitrogen-containing heterocyclic group can be substituted with 1 substitute selected from hydroxy group, amino group, diC1-6alkylamino group and C1-6alkyl group (C1-6alkyl group can be substituted with diC1-6alkylamino group)). Values of other substitutes are given in patent claim. Invention also relates to a medicinal agent as a macrolide antibiotic for prevention and/or therapeutic treatment of various microbial infectious diseases, containing disclosed compound as an active ingredient, and to a compound of formula (VIII).EFFECT: technical result is obtaining novel compounds having strong antibacterial activity.20 cl, 22 tbl, 576 exИзобретение относится к соединению формулы (I) и его фармацевтически приемлемым солямгде Me представляет
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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