T CELLS EXPRESSING MEMBRANE-ANCHORED IL-12 FOR THE TREATMENT OF CANCER

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专利权人:

BOARD REGENTS; THE UNIVERSITY OF TEXAS SYSTEM

发明人:

Shulin LI,Jiemiao HU,Xueqing XIA

申请号：

US16339691

公开号：

US20200048322A1

申请日:

2017.10.06

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane-anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T cell chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer.

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