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RNA viruses expressing IL-12 for immunovirotherapy
专利权人:
DEUTSCHES KREBSFORSCHUNGSZENTRUM;RUPRECHT-KARLS UNIVERSITAET
发明人:
Guy Ungerechts,Christine Engeland,Ruta Veinalde
申请号:
US15441545
公开号:
US10344067B2
申请日:
2017.02.24
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding an IL-12 polypeptide, wherein said IL-12 polypeptide is an IL-12 fusion polypeptide comprising a p35 subunit of an IL-12 and a p40 subunit of an IL-12; to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.
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