Provided herein inter alia are compositions and methods for preserving platelets in a lesion free and functional state during extended storage periods of up to 15 days as well as methods and kits for utilizing the same. In contrast to currently available compositions and techniques for preserving platelets platelets stored in the compositions disclosed herein are characterized by a marked decrease in storage lesions which are associated with attenuated hemostatic function. During platelet storage the compositions disclosed herein (1) maintain and/or restore platelet energy states and morphology (2) maintain active metabolism and buffering (3) preserve and/or promote nitric oxide production and (4) prevent microparticle formation aggregation and activation during storage. As such long term preservation in the compositions described herein produce platelets that are fully functional and lesion free.
