Tong Pu,Yi Fan,Tian Chen,Ming Lei,Naixing Wang,Zhen Yang,Jianming Yang
申请号：
US13259466
公开号：
US09084792B2
申请日:
2010.03.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Preparation of acyclovir 2/3 hydrate comprises mixing acyclovir with water at weight ratio of 1:5˜50, dissolving at 50˜100° C., filtering, cooling filtrate at 0˜30° C. to precipitate crystal, collecting the crystal by filtration, and drying the crystal at 0˜150° C. for 0.5˜24 hours to obtain acyclovir 2/3 hydrate. The preparation process is simple and suitable for industrial production. The prepared product has good and stable crystal form.
