PROBLEM TO BE SOLVED: To provide a novel molecule having an ability to specifically bind to and inhibit TLR-4 and to be useful as a therapeutic agent, and uses thereof. A nucleic acid aptamer that has the ability to specifically bind to and inhibit TLR-4, has a specific nucleic acid sequence, and has a functionally equivalent variant thereof. [Selection diagram] None【課題】TLR-4に特異的に結合してそれを阻害する能力を有し、且つ、治療薬として有用である新規の分子およびそれらの用途を提供する。【解決手段】TLR-4に特異的に結合してそれを阻害する能力を有し、且つ、特定の核酸配列を有しその機能的に同等の変異体を備える核酸アプタマー。【選択図】なし