BOY, KENNETH M.,GUERNON, JASON M.,MACOR, JOHN E.,OLSON, RICHARD E.,SHI, JIANLIANG,THOMPSON III, LORIN A.,WU, YONG-JIN,XU, LI,ZHANG, YUNHUI,ZUEV, DMTRY
申请号：
PE0001342012
公开号：
PE08972012A1
申请日:
2010.07.28
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Relates to Heterocyclic compounds of formula (i) where a is a Ring of 5 or 6 members heteroaromatico optionally replaced with Halo, Hydroxy, amino, among others b is phenyl or pyridinyl optionally substituted with alkoxy (C1 - C6), alkyl (C1 - C6), CN, Halo, among others d a Compound Formula (i), (ii), (iii), among others, where RB is nrxry, where RX and ry are each h,Alkoxy (c1-c4), (c1-c4) - alkoxy alkyl (c1-c4), among others E (C1 - C6 alkyl, cycloalkyl) (C4, C6) benzyl, phenyl, among others.Preferred compounds are: N2 - (3 - (4 - methoxy - 3 - methyl - 1h-1,2,4-triazole - 1 - yl) - phenyl) - N4 - 7 - methyl phenyl 6,7-dihydro-5h-cyclopenta [d] pyrimidine - 2.4 - diamine 4 - (1 - azetidin - ilo) - N - (4 - (4 - chlorine - 1h imidazole - 1 - yl) - 3 - metoxifenilo) - 7 - phenyl - 6,7-dihydro-5h-cyclopenta [d] pyrimidine 2 Amine 4 - ((1S, 4S) - 2 - azabic oxa - 5 - Imo-i2500en [2.2.1] heptan - 5 - yl) - N - (4 - (4 - chlorine - 1H imidazole - 1 - yl) - 3 - metoxifenilo) - 7 - (4 - fluorofenilo) - 6,7-dihydro-5h-cyclopenta [d] pyrimidine 2 Amine among others. It also relates to a Pharmaceutical composition. These compounds are inhibitors of the beta Amyloid Peptide Production being useful in the treatment of Alzheimers disease, Downs syndromeSE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE A ES UN ANILLO HETEROAROMATICO DE 5 O 6 MIEMBROS OPCIONALMENTE SUSTITUIDO CON HALO, HIDROXI, AMINO, ENTRE OTROS B ES FENILO O PIRIDINILO OPCIONALMENTE SUSTITUIDOS CON ALCOXI(C1-C6), ALQUILO(C1-C6), CN, HALO, ENTRE OTROS D ES UN COMPUESTO DE FORMULA (i), (ii), (iii), ENTRE OTROS, EN DONDE Rb ES -NRxRy, DONDE Rx Y Ry SON CADA UNO H, ALCOXI(C1-C4), ALCOXI(C1-C4)-ALQUILO(C1-C4), ENTRE OTROS E ES ALQUILO(C1-C6), CICLOALQUILO(C4-C6), BENCILO, FENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N2-(3-METOXI-4-(3-METIL-1H-1,2,4-TRIAZOL-1-ILO)FENILO)-N4-METIL-7-FENIL-6,7-DIHIDRO-5H-CICLOPENTA[d]PIRIMIDINA-2,4-DIAMINA 4-(AZETIDIN-1-ILO)-N-(4-(4-CLORO-1H-IMIDAZOL-1-ILO)-3-METOXIFENILO
