CURRIE, KEVIN S.,BLOMGREN, PETER A.,KROPF, JEFFREY E.,LEE, SEUNG H.,XU, JIANJUN,STAFFORD, DOUGLAS G.,MITCHELL, SCOTT A.
申请号：
PE0011852011
公开号：
PE01212012A1
申请日:
2009.12.07
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of formula (i) wherein R1 is pirazolilo pyridinyl, piridazinilo, replaced or not, among others R2 Is 2,3 Dimethyl 2H - indazol - 6-yl, indazolil - 6-yl 1H - 1H -, 1 - methyl - 3 - 6 - indazol ILO, aminoquinilin - 6 - - ILO, among others R3 is R4 R5 h, h, h.Preferred compounds are: N - [6 - (1H - indazol - 6 - il) imidazo [1,2-a] 8 - yl] - 1H - 1.3 - benzodiazol - 6 - 3 - cyclopropyl Amine n - [6 - (1H - indazol IL - 6 - imidazo [1,2-a) pirazin - il - 8]] - 1H pyrazole - 5 - (Amine 7 - 8 - {[1 - (2-hydroxyethyl) - 1h-pyrazol-4-yl] imidazo [1,2A] amino} - il - 6 pirazin) - 1H, 2H, 3H pirido [2,3-b] [1.4] oxazin - 2 - One among others. Also referred to a Pharmaceutical composition.This Compound is an inhibitor of the Spleen Tyrosine Kinase (SYK) useful in the treatment of allergic disorders, autoimmune diseases and inflammatory diseasesSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES PIRIDINILO, PIRIDAZINILO, PIRAZOLILO SUSTITUIDO O NO, ENTRE OTROS R2 ES 2,3-DIMETIL-2H-INDAZOL-6-ILO, 1H-INDAZOLIL-6-ILO, 1-METIL-1H-INDAZOL-6-ILO, 3-AMINOQUINILIN-6-ILO, ENTRE OTROS R3 ES H, R4 ES H R5 ES H. SON COMPUESTOS PREFERIDOS: N-[6-(1H-INDAZOL-6-IL)IMIDAZO[1,2-a]PIRAZIN-8-IL]-1H-1,3-BENZODIAZOL-6-AMINA 3-CICLOPROPIL-N-[6-(1H-INDAZOL-6-IL)IMIDAZO[1,2-a]PIRAZIN-8-IL]-1H-PIRAZOL-5-AMINA 7-(8-{[1-(2-HIDROXIETIL)-1H-PIRAZOL-4-IL]AMINO}IMIDAZO[1,2a]PIRAZIN-6-IL)-1H, 2H,3H-PIRIDO[2,3-b][1,4]OXAZIN-2-ONA ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES INHIBIDOR DE LA TIROSINA CINASA DEL BAZO (SYK) UTIL EN EL TRATAMIENTO DE TRANSTORNOS ALERGICOS, ENFERMEDADES AUTOINMUNITARIAS Y ENFERMEDADES INFLAMATORIAS
