A ventilator with an integrated cough assist for use with a patient circuit in fluid communication with a patient connection of a patient, and operable in a ventilation mode and in a cough-assist mode. The ventilator includes a user input for switching operation from ventilation mode to cough-assist mode without disconnecting the ventilator from the patient, and a controller operable in response to the user input and controlling operation of the ventilator in cough-assist mode to provide for at least one cough assist to the patient having an insufflation phase followed by an exsufflation phase. A cough-assist valve in a first state for the insufflation phase communicates a positive pressure to the ventilator connection and in a second state for the exsufflation phase communicates a negative pressure to the ventilator connection.
