對電位閘控鈉通道具選擇活性之羥基烷基胺－及羥基環烷基胺－取代之二胺

发明人:: GRESHOCK, THOMAS J.,葛沙克　汤玛士　Ｊ,葛沙克　湯瑪士　Ｊ,MULHEARN, JAMES,穆尔横　詹姆士,穆爾橫　詹姆士,ZHENG, JUNYING,丁　俊景,KIM, RONALD M.,金　罗南德　Ｍ,金　羅南德　Ｍ,ZHANG, TING,张婷,張婷,ROECKER, ANTHONY J.,罗克尔　安东尼　Ｊ,羅克爾　安東尼　Ｊ,WON, WALTER,汪　,葛沙克汤玛士 J,葛沙克湯瑪士 J,穆尔横詹姆士,穆爾橫詹姆士,丁俊景,金罗南德 M,金羅南德 M,罗克尔安东尼 J,羅克爾安東尼 J,汪

摘要：: Disclosed are compounds ofFormula A, or a salt thereof:Formula A, wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.本發明揭示式A之化合物或其鹽:式A，其中R1、R2及E在本文中定義，該等化合物具有抑制周邊神經元及交感神經元中發現之Nav1.7離子通道的性質。亦描述包含式A之化合物或其鹽之醫藥調配物及使用該醫藥調配物治療疼痛病症、咳嗽及瘙癢之方法。