This invention relates to compounds of general formula in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.本發明係關於下示通式之化合物(其中,R1、R2、U、V、L、M、R5、m、X、Y及Z係如本文中所定義者),以及其藥學上可接受的鹽類、包含此類化合物及鹽類的藥學組成物、以及使用此類化合物、鹽類及組成物來治療異常細胞生長(包括癌症)的方法。