Imidazopyridazines as Akt kinase inhibitors

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专利权人:

Bayer Intellectual Property GmbH;Bayer Pharma Aktiengesellschaft

发明人:

BÄRFACKER, Lars,SCOTT, William Johnston,HÄGEBARTH, Andrea,INCE, Stuart,REHWINKEL, Hartmut,POLITZ, Oliver,NEUHAUS, Roland,BRIEM, Hans,BÖMER, Ulf

申请号：

ES12713963

公开号：

ES2558780T3

申请日:

2012.04.05

申请国别(地区):

ES

年份:

2016

代理人:

摘要：

A compound of formula (I) ** Formula ** in which R1 is hydrogen, hydroxy, NR5R6, halogen, cyano, CO (NR8R9), C (O) OR8, C (O) (C1-6 alkyl), NHC (O) (C1-6 alkyl), NHS (O) 2R11, NHC (O) NHR11, -S (O) n-C1-6 alkyl, -S (O) 2NR5R6 or a group selected from alkyl of C1-6, C1-6 alkoxy, C3-7 cycloalkyl, aryl, heteroaryl, - (C1-6 alkyl) -aryl, - (C1-6 alkyl) -heteroaryl, -O- (C3- cycloalkyl 7), -O-aryl, -O- (C3-7 heterocyclyl), -O-heteroaryl, -O- (C1-6 alkyl) -heteroaryl, -O- (C1-6 alkyl) - (heterocyclyl C3-7), -O- (C1-6 alkyl) -aryl, C2-6 alkenyl, C2-6 alkynyl, wherein said group is optionally substituted, one or more times, identically or differently , with a substituent selected from: hydroxy, halogen, C1-6 alkyl, C1-4 haloalkyl, C1-6 alkoxy, -NR8R9, cyano, -C (O) NR8R9, -C (O) OR10, -NHC (O) R11, -NHC (O) NHR11, -NHS (O) 2R11, C3-7 cycloalkyl, C3-7 heterocyclyl, aryl, R2 is hydrogen, hydroxy, NR5R6, h halogen, cyano, CO (NR8R9), C (O) OR8, C (O) (C1-6 alkyl), NHC (O) (C1-6 alkyl), NHS (O) 2R11, NHC (O) NHR11 , -S (O) n-C1-6 alkyl, -S (O) 2NR5R6 or a group selected from C1-6 alkyl, C1-6 alkoxy, C3-7 cycloalkyl, aryl, heteroaryl, - (alkyl C1-6) -aryl, - (C1-6 alkyl) -heteroaryl, -O- (C3-7 cycloalkyl), -O-aryl, -O- (C3-7 heterocyclyl), -O-heteroaryl , -O- (C1-6 alkyl) -heteroaryl, -O- (C1-6 alkyl) - (C3-7 heterocyclyl), -O- (C1-6 alkyl) -aryl, C2 alkenyl 6, C2-6 alkynyl, wherein said group is optionally substituted, one or more times, identically or differently, with a substituent selected from: hydroxy, halogen, C1-6 alkyl, C1-4 haloalkyl, C1-6 alkoxy, -NR8R9, cyano, -C (O) NR8R9, -C (O) OR10, -NHC (O) R11, -NHC (O) NHR11, -NHS (O) 2R11, C3 heterocyclyl 7, aryl, R3 is hydrogen, hydroxy, NR5R6, halogen, cyano, CO (NR8R9), C (O) OR8, C (O) (C1-6 alkyl), NHS (O) 2R11, NHC (O) NHR11 , -S (O) n-C1-6 alkyl, -S (O) 2NR5R6 or a group selected from C1-6 alkyl, C1-6 alkoxyC3-7 cycloalkyl, aryl, heteroaryl, - (C1-6 alkyl) -aryl, - (C1- alkyl 6) -heteroaryl, -O- (C3-7 cycloalkyl), -O-a

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