CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQU;UNIVERSITE PARIS DESCARTES;(NSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP);FONDATION IMAGINE
The inventors demonstrate for the first time the activation of the Hedgehog (HH) signaling pathway in normal and abnormal human mast cells (MCs). These results prompt the inventors to explore the consequence of the inhibition of the HH pathway, especially the canonical pathway, on MC proliferation. They demonstrate that Hedgehog inhibitors inhibit proliferation and induces apoptosis of mast cells. Accordingly the present invention relates to a method of treating a mast cell disease in a patient in need there of comprising administering to the patient a therapeutically effective amount of a Hedgehog inhibitor.
