Institut National de la Santé et de la Recherche Médicale (INSERM);Fondation Imagine;Université Paris Descartes;Assistance Publique-Hôpitaux de Paris (APHP);Centre National de la Recherche Scientifi
发明人:
申请号：
EP18724562.6
公开号：
EP3624798A1
申请日:
2018.05.17
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The inventors demonstrate for the first time the activation of the Hedgehog (HH) signaling pathway in normal and abnormal human mast cells (MCs). These results prompt the inventors to explore the consequence of the inhibition of the HH pathway, especially the canonical pathway, on MC proliferation. They demonstrate that Hedgehog inhibitors inhibit proliferation and induces apoptosis of mast cells. Accordingly the present invention relates to a method of treating a mast cell disease in a patient in need there of comprising administering to the patient a therapeutically effective amount of a Hedgehog inhibitor.
