Non human transgenic animals produce modified antibodies that contain only heavy chains

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专利权人:

ТЕНЕОБИО; ИНК. (US)

发明人:

ВАН СХОТЕН, Вим (US),ТРИНКЛАЙН, Натан (US),ФОРС-АЛЬДРЕД, Шелли (US),БРЮГГЕМАНН, Марианна (US),ОСБОРН, Майкл (US)

申请号：

RU2019108240

公开号：

RU2019108240A

申请日:

2017.08.22

申请国别(地区):

RU

年份:

2020

代理人:

摘要：

Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupting a surface-exposed hydrophobic patch comprising or associated with the native amino acid residue at that position.

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