Wim van Schooten,Nathan Trinklein,Shelley Force-Aldred,Marianne Bruggemann,Mike Osborn
申请号：
US16327299
公开号：
US20190225671A1
申请日:
2017.08.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupting a surface-exposed hydrophobic patch comprising or associated with the native amino acid residue at that position.
