Alessandro Falchi,Daniele Andreotti,Giuseppe Alvaro,Riccardo Giovannini,Romano Di Fabio,Sandro Belvedere
申请号：
BRPI0615787
公开号：
BRPI0615787B1
申请日:
2006.09.07
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
pyridine derivatives and their use in the treatment of psychotic disorders are proposed according to the invention edict compounds of the formula (i) or a pharmaceutically acceptable salt thereof: (i) in which: x represents a nitrogen atom； y represents -c (h (2)) -, (-c (h (2)) -) (2), -s (o (2)) - or -c (= o) -； z represents -c (h (2)) -, -s (o (2)) -, -n (r (z)) -, or an oxygen or sulfur atom； a represents hydrogen or -ch (2) oh； r (z) represents hydrogen, c (1-6) alkyl, c (1-6) alkoxy, - color (7) or -so (2) r7)； r (1) represents halogen, c (1-6) alkyl, c (1-6) alkoxy, = o, c (1-6) halo-alkyl, c (1-6) halo-alkoxy, hydroxyl or -ch (2) oh； m represents an integer from 0 to 3； r (2) represents halogen, = o, c (1-6) alkyl (optionally substituted by one or more hydroxyl groups), -coor (7) -conr (7) r (8), c (1-6) alkoxy , halo c (1-6) alkyl, c (1-6) alkoxy or ((c1-6)) alkyl o (1-6) alkyl； n represents an integer from 0 to 3； p and q independently represent an integer from 0 to 2； r (3) represents a group - aryl, -heteroaryl, -heterocyclyl, -aryl-aryl, -aryl-etheraryl, -aryl-heterocyclyl, -heteroaryl-aryl, - heteroaryl-heteroaryl, -heteroaryl-heterocyclyl, - heterocyclyl-aryl , -heterocyclyl-heteroaryl or - heterocyclyl-heterocyclyl, all of which can optionally be replaced by one or more (1, 2 or 3, for example) allogens, alkyl groups (1-6) (optionally substituted) by one or more groups hydroxyl), cycloalkyl c (3-8), alkoxy c (1-6), hydroxyl, haloalkyl c (1-6), haloalkoxy c (1-6), cyano, -s-alkyl c (1-6), -so-alkyl c (1-6), -so (2) -alkyl (1-6), -color (7), -conr (7) r (8), -nr (7) r (8), -nr (7) co-alkyl c (1-6), -nr (7) so (2) -alkyl c (1-6), alkyl (c (1-6)) -nr (7) r (8 ), -oconr (7) r (8), -nr (7) co (2) r (8) or -s0 (2) r (7) r (8)； r (4) and r (5) independently represent c (1-6) alkyl, or r (4) er (5), together with the carbon atom to which they are attached, can together form a cycloalkyl group c (3- 8)； s represents an integer from 0 to 4； r (7) and r (8) inde
