The present invention includes oral care compositions and methods for inhibiting growth and formation of oral biofilms by quorum sensing inhibition and/or bactericidal activity. In some embodiments, the present invention discloses an oral care composition including a therapeutically effective amount of at least one carbonate compound offormula 1and at least one excipient:wherein, R1and R2are independently: an aliphatic radical； a hydroxyaliphatic radical； or an aryl radical.In some embodiments, the present invention discioses a method of providing oral care benefits including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least one carbonate compound offormula 1and at least one excipient. In some embodiments, the present invention discloses a method of up-reguiating or down-regulating periodontal disease metabolites including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least one carbonate compound offormula 1and at least one excipient.本發明包含口腔保健組成物及用於經由群體密度感應(quorum sensing)抑制作用及/或殺菌劑活性而抑制口腔生物膜之生長及形成之方法。於某些具體實施例中，本發明揭示一種口腔保健組成物，其包含治療有效量之至少一種式1之碳酸酯化合物及至少一種賦形劑：其中，R1及R2獨立地係：脂族基團、羥基脂族基團、或芳基基團。於某些具體實施例中，本發明揭示一種提供口腔保健利益之方法，其包含將一種包含治療有效量之至少一種式1之碳酸酯化合物及至少一種賦形劑之口腔保健組成物塗敷至口腔。於某些具體實施例中，本發明揭示一種向上調節(up-regulating)或向下調節(down-regulating)牙周疾病代謝產物之方法，其包含將一種包含治療有效量之至少一種式1之碳酸酯化合物及至少一種賦形劑之口腔保健組成物塗敷至口腔。
