THE PRESENT INVENTION INCLUDES ORAL CARE COMPOSITIONS AND METHODS FOR INHIBITING GROWTH AND FORMATION OF ORAL BIOFILMS BY QUORUM SENSING INHIBITION AND/OR BACTERICIDAL ACTIVITY. IN SOME EMBODIMENTS, THE PRESENT INVENTION DISCLOSES AN ORAL CARE COMPOSITION INCLUDING A THERAPEUTICALLY EFFECTIVE AMOUNT OF AT LEAST ONE CARBONATE COMPOUND OF FORMULA 1 AND AT LEAST ONE EXCIPIENT: WHEREIN, R1 AND R2 ARE INDEPENDENTLY: AN ALIPHATIC RADICAL； A HYDROXYALIPHATIC RADICAL； OR AN ARLY RADICAL. IN SOME EMBODIMENTS, THE PRESENT INVENTION DISCLOSES A METHOD OF PROVIDING ORAL CARE BENEFITS INCLUDING APPLYING TO AN ORAL CAVITY AN ORAL CARE COMPOSITION CONTAINING A THERAPEUTICALLY EFFECTIVE AMOUNT OF AT LEAST ONE CARBONATE COMPOUND OF FORMULA 1 AND AT LEAST ONE EXCIPIENT. IN SOME EMBODIMENTS, THE PRESENT INVENTION DISCLOSES A METHOD OF UP-REGULATING OR DOWN-REGULATING PERIODONTAL DISEASE METABOLITES INCLUDING APPLYING TO AN ORAL CAVITY AN ORAL CARE COMPOSITION CONTAINING A THERAPEUTICALLY EFFECTIVE AMOUNT OF AT LEAST ONE CARBONATE COMPOUND OF FORMULA 1 AND AT LEAST ONE EXCIPIENT.
