SCHANN, STEPHAN,MAYER, STANISLAS,MORICE, CHRISTOPHE,GIETHLEN, BRUNO
申请号：
ES10781455
公开号：
ES2522827T3
申请日:
2010.10.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of the general formula (I) ** Formula ** in which: R1, R2, R3 and R4 each independently represent a group -LR, in which: L is selected from a bond, C1-C10 alkylene, C2-C10 alkenylene or C2-C10 alkynylene, wherein said alkylene, said alkenylene or said alkynylene are optionally substituted with one or more groups independently selected from halogen, -CF3, -CN, -OH or -NH2, and additionally, wherein one or more units of -CH2- comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from: -O-, -NR11-, -CO-, -S-, -SO-, or -SO2-； R is selected from hydrogen, C1-C10 alkyl, halogen, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, -NR11R12, -OR11, -SR11, -SOR11, -SO2R11, -CF3 or -CN, wherein said optionally substituted aryl, said optionally substituted heteroaryl, said optionally substituted cycloalkyl or said optionally substituted heterocycloalkyl may be substituted with one or more groups independently selected from C1-C4 alkyl, halogen, -CF3, -CN, -OH, -O (C1-C4 alkyl), -NH2, -NH (C1-C4 alkyl), -N (C1-C4 alkyl) (C1-C4 alkyl) wherein the two C1-C4 alkyl moieties of said -N (C1-alkyl) C4) (C1-C4 alkyl) are optionally crimped together to form a ring together with the nitrogen atom to which they are attached, or -L1-R13； Each of R11 and R12 is independently selected from hydrogen, optionally substituted C1-C10 alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, or -CF3, wherein said optionally substituted alkyl, said optionally substituted aryl , said optionally substituted heteroaryl, said optionally substituted cycloalkyl or said optionally substituted heterocycloalkyl may be substituted with one or more groups independently selected from C1-C4 alkyl, halogen, -CF3, -CN, -OH, -O (C1-C4 alkyl) , -NH2, -NH (C1-C
