LEE, Kang Choon,LEE, Sung Kwon,CHAE, Su Young,YOUN, Yu Seok,KIM, Won Bae
申请号：
DK07746877
公开号：
DK2026842T3
申请日:
2007.06.12
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG-TAIL conjugate exhibits high solubility and solution stability, with highly improved pharmacokinetic profiles. Thus, the PEG-TAIL conjugate may be very useful for preventing and treating proliferative diseases and autoimmune diseases.
