Refers to a compound of formula (i) wherein R1 is c1-c6 alkyl, cycloalkyl C1 - C6, among others R2, R3, R4, R5 and R6 are H or alkyl of C1 - C3 alkyl R4 is C1 - C6, cicloaquilo C1 - C6Among others, ra and RB are combined with the nitrogen Atom to which they are United to form a group or a Heterocyclic Group espirociclico.Preferred compounds are: 4 - (ciclopropilimidazol - 1 - il) - N - [2 - (4 - 2-cyclopropyl-1 - 1,2,4-triazole - 3 - - 1.3 - il) thiazol-4-yl] - 5 - [3 - (difluorometil) azetidin - triazin-1-yl] pyridine - 2 - carboxamide,5 - (3 - cianoazetidin - 1 - il) - 4 - (ciclopropilimidazol - 1 - il) - N - [2 - (4 - 2-cyclopropyl-1 - 1,2,4-triazole - 3 - - 1.3 - il) thiazol-4-yl] pyridine - 2 - carboxamide, among others.It also relates to a Pharmaceutical Composition and a kit comprising Said composition.These compounds have Inhibitory activity of Apoptosis Signal Regulating Kinase (SK1) is useful in the treatment of conditions mediated by Disorders such as autoinmu SK1Nes, cardiovascular, diabetes, among othersReferida a un compuesto de formula (I) donde R1 es alquilo C1-C6, cicloalquilo C1-C6, entre otros R2, R3, R4, R5 y R7 son H o alquilo C1-C3 R6 es alquilo C1-C6, cicloaquilo C1-C6, entre otros Ra y Rb se combinan con el atomo de nitrogeno al cual estan unidos formando un grupo heterociclico o un grupo espirociclico. Son compuestos preferidos: 4-(4-ciclopropilimidazol-1-il)-N-[2-(4-ciclopropil-1,2,4-triazol-3-il)-1,3-tiazol-4-il]-5-[3-(difluorometil)azetidin-1-il]piridina-2-carboxamida, 5-(3-cianoazetidin-1-il)-4-(4-ciclopropilimidazol-1-il)-N-[2-(4-ciclopropil-1,2,4-triazol-3-il)-1,3-tiazol-4-il]piridina-2-carboxamida, entre otros. Tambien se refiere a una composicion farmaceutica y a un kit que comprende dicha composicion. Dichos compuestos tienen actividad inhibitoria de la quinasa reguladora de la senal de apoptosis (ASK1) siendo utiles en el tratamiento de condiciones mediadas por ASK1 tales como trastornos autoinmunes, cardiovasculares, diabetes, ent
