Refers to indole derivative compounds of formula (i) where x1 and x2 are each C o n y1 is aryl or - C (R2) (R3) (R4), where R2 is H, alkyl - or - (C1 - C6), - Oh, - CN, among others R3 and R4 are Each h, alkyl (C1 - C6), haloalquilo (C1 - C6), aryl, among others each Y2 and Z is H or alkyl (C1 - C6 A1a) and r1b are each h, halogen, alkyl - or - (C1 - C6), or haloalquilo (C1 - C6)Among others, the dotted lines are a simple link or double.Preferred compounds are: acid [6 - (4 - benzyl triazole - [1,2,3] - 1 - il) - - tetrahidropirido 6,7,8,9 [1,2-a] indole - 10 - yl] - acetic acid, 3 - (5 - [benzyl triazole - [1,2,3] - 1 - il) - 1,2,3,4 Tetrahydro CARBAZOLE - - - 9 - yl] - acetic acid tert butyl ester 4 - [3 - (10 - Carboxymethyl - tetrahidropirido 6,7,8,9 [1,2-a] indole - 3 - 7 - il) H - [1,2,3] triazol yl] - 4 - piperidine - 1 - carboxylic acid among others.It also relates to a Pharmaceutical composition that contains Pranlukast or montelukast, zafirlukast. These compounds are antagonists of chemoattractant receptor expressed in Th2 Cells (CRTH2) being useful in the treatment of allergic rhinitis, asthmaSE REFIERE A COMPUESTOS DERIVADOS DE INDOL DE FORMULA (I) DONDE X1 Y X2 SON CADA UNO C O N Y1 ES ARILO O -C(R2)(R3)(R4), EN DONDE R2 ES H, -O-ALQUILO(C1-C6), -OH, -CN, ENTRE OTROS R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6), HALOALQUILO(C1-C6), ARILO, ENTRE OTROS Y2 Y Z SON CADA UNO H O ALQUILO(C1-C6) R1a Y R1b SON CADA UNO H, HALOGENO, -O-ALQUILO(C1-C6), -O-HALOALQUILO(C1-C6), ENTRE OTROS LAS LINEAS PUNTEADAS SON UN ENLACE SIMPLE O DOBLE. SON COMPUESTOS PREFERIDOS: ACIDO [7-(4-BENCIL-[1,2,3]TRIAZOL-1-IL)-6,7,8,9-TETRAHIDROPIRIDO[1,2-a]INDOL-10-IL]-ACETICO ACIDO [3-(5-BENCIL-[1,2,3]TRIAZOL-1-IL)-1,2,3,4-TETRAHIDRO-CARBAZOL-9-IL]-ACETICO ESTER TERC-BUTILICO DEL ACIDO 4-[3-(10-CARBOXIMETIL-6,7,8,9-TETRAHIDROPIRIDO[1,2-a]INDOL-7-IL)-3H-[1,2,3]TRIAZOL-4-IL]-PIPERIDINA-1-CARBOXILICO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ADEMAS CONTIENE MONTELUKAST,
