ANDERSON, JAMES THOMAS,CHEKLER, EUGENE LVOVICH PIATNITSKI,ELLSWORTH, EDMUND L.,ERICKSON, BRUCE KIPP,GILBERT, ADAM MATTHEW,RICKETTS, ANTHONY P.,THOMPSON, DAVID P.,UNWALLA, RAYOMAND JAL,VERHOEST, PATRIC
申请号：
PE0007202015
公开号：
PE11582015A1
申请日:
2013.11.25
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The Invention relates to a compound of Formula 1, 2 or 3: where a is - n or - CR0, where R0 is Hydrogen, linear or branched chain Alkyl of C1 - C6, etc., X and y are independently - CH2 -, etc. Z is cre - or, - N -, where re is Hydrogen, linear or branched chain Alkyl of C1 - C 6, etc. r1 is Hydrogen, linear or branched chain Alkyl of C1 - C6, etc. R2 are independently Hydrogen or linear or branched chain Alkyl of C1 - C6 R3 and R4 are independently Hydrogen, linear or branched chain Alkyl of C1 - C6, etc. R5 and R6 are independently Hydrogen or linear or branched chain Alkyl of C1 - C6, R8 is Hydrogen, etc. Lquilo linear chain or branched C1 - C6, etc. R9 and R10 are independently Hydrogen or linear or branched chain Alkyl of C1 - C6, etc. Q is - CO - (CH2) Q, - - - - - - - - (CHRS) Q, or Q - - - (crsrt), where RS and RT are whether linear or branched chain Alkyl of C1 - C6, aryl, heteroaryl or alkylaryl, where q is alquilheteroarilo 0, 1, 2, or 3 and where n is 0, 1, 2, 3, 4 or 5 or a pharmaceutically acceptable Salt of Same, compositions containing such compounds.The composition is useful for Treatment of diseases affected by androgen receptorLa invencion se refiere a un compuesto de la formula 1, 2 o 3: en donde A es N o -CR0-- , donde R0 es hidrogeno, alquilo de cadena lineal o ramificada de C1-C6, etc., X e Y son independientemente-CH2--, etc. Z es -CRe--, o, -N--, donde Re es hidrogeno, alquilo de cadena lineal o ramificada de C1-C6, etc. R1 es hidrogeno, alquilo de cadena lineal o ramificada de C1-C6, etc. R2 son independientemente hidrogeno o alquilo de cadena lineal o ramificada de C1-C6 R3 y R4 son independientemente hidrogeno, alquilo de cadena lineal o ramificada de C1-C6, etc. R5 y R6 son independientemente hidrogeno o alquilo de cadena lineal o ramificada de C1-C6, etc. R8 es hidrogeno, alquilo de cadena lineal o ramificada de C1-C6, etc. R9 y R10 son independientemente hidrogeno o alquilo de cadena lineal o ramificada de C1-C6, etc. Q es -CO-- , --(C
