Patrick Robert VERHOEST,Eugene Lvovich Piatnitski CHEKLER,Adam Matthew GILBERT,Rayomand Jal UNWALLA,James Thomas ANDERSON
申请号：
MX2016015467
公开号：
MX2016015467A
申请日:
2015.05.18
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The present invention relates to a compound of Formula 1, 2 or 3: I II III wherein A is N or -CR0--, where R0 is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is -CRe --, or, -N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl, etc.； R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.； R2 are independently hydrogen or C1-C6 linear or branched chain alkyl； R3 and R4 are independently hydrogen, C1C6 linear or branched chain alkyl, etc.；. R5 and R6 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.； R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.； R9 and R10 are independently hydrogen or C1- C6 linear or branched chain alkyl, etc.； Q is --CO--, --(CH2)q--, --(CHRs)q--, or -(CRsRt)q- -, where Rs and Rt are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl； where q is 0, 1, 2, or 3； and, where >；n>； is 0, 1, 2, 3, 4 or 5； or, a pharmaceutically acceptable salt thereof, for the treatment of certain diseases, particularly those affected or mediated by the androgen receptor； to compbinations comprising such compounds with a second pharmaceutically active ingredient； to compositions containing such combinations； and to such combinations for the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.La presente invención se refiere a un compuesto de la Fórmula 1, 2 o 3: (ver Fórmula) en donde A es N o -CR0--, en donde R0 es hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc., Z es -CRe --, o, -N--, en donde Re es hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc.； R1 es hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc.； R2 son independientemente hidrógeno o C1-C6 alquilo de cadena lineal o ramificada； R3 y R4 son independientemente hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc.；. R5y R6 son independientemente hidrógeno o C1-C6 alquilo de cadena lineal o ramificada, etc.； R8
