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NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
专利权人:
ASTELLAS PHARMA INC.
发明人:
KAMEDA, MINORU,KURIWAKI, IKUMI,IIKUBO, KAZUHIKO,HISAMICHI, HIROYUKI,KAWAMOTO, YUICHIRO,MORITOMO, HIROYUKI,SUZUKI, TOMOYUKI,FUTAMI, TAKASHI,SUZUKI, ATSUSHI,TSUNOYAMA, KAZUHISA,ASAUMI, MAKOTO,TOMIYAMA,
申请号:
EP13754501
公开号:
EP2821402A4
申请日:
2013.02.26
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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