NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY;TRANS CHROMOSOMICS, INC.
发明人:
KAZUKI, YASUHIRO,ABE, SATOSHI,OSHIMURA, MITSUO
申请号：
CA3042171
公开号：
CA3042171A1
申请日:
2017.10.31
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present application provides: a non-human animal which is stably maintained in progeny and can produce human antibodies, and which is characterized by including a mouse artificial chromosome that contains a human antibody heavy chain gene or gene locus, and a human antibody ? light chain gene or gene locus and/or a human antibody ? light chain gene or gene locus, and in that at least two endogenous antibody genes or gene loci each corresponding to a human antibody gene or gene locus have been knocked out； a preparation method for the non-human animal； and a method for producing human antibodies using the non-human animal.
