Burova Elena,Tang Yajun,Lai Ka-Man Venus,Murphy Andrew J.
申请号：
US201815883477
公开号：
US2018160663(A1)
申请日:
2018.01.30
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Cluster of Differentiation 274 (CD274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD274 gene so that said non-human animals express a Programmed cell death ligand 1 (PD-L1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
