NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY;TRANS CHROMOSOMICS, INC.
发明人:
Yasuhiro KAZUKI,Satoshi ABE,Mitsuo OSHIMURA
申请号：
US16346077
公开号：
US20190254264A1
申请日:
2017.10.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This application provides: a non-human animal that comprises a mouse artificial chromosome comprising a human antibody heavy chain gene or gene locus, a human antibody light chain κ gene or gene locus, and/or a human antibody light chain λ gene or gene locus, and in which endogenous antibody genes or gene loci corresponding to at least 2 human antibody genes or gene loci have been knocked out, wherein the animal can be stably retained through generations and can produce human antibodies； a method for producing the non-human animal； and a method for producing human antibodies using the non-human animal.
