ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM;CRAIG, ROGER KINGDON
发明人:
申请号：
EP09760275.9
公开号：
EP2379727B1
申请日:
2009.11.30
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
A non-human mammal containing an endogenous lambda light chain gene locus, an endogenous kappa light chain gene locus and an endogenous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge but said loci have been mutated so that the ability to form functional immunoglobulin tetramers comprising re-arranged heavy and light chains produced from said mutated loci has been substantially reduced or eliminated.
