ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM;CRAIG, ROGER KINGDON
发明人:
GROSVELD, FRANKLIN GERARDUS,JANSSENS, RICHARD WILHELM,VAN HAPEREN, MARINUS JOHANNES,CRAIG, ROGER KINGDON
申请号：
CA2747534
公开号：
CA2747534C
申请日:
2009.11.30
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
A non-human mammal containing an endogenous lambda light chain gene locus, anendogenous kappa light chaingene locus and an endogenous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and lightchain genes are formed and expressed in B-cells following antigen challengebut said loci have been mutated so that the ability toform functional immunoglobulin tetramers comprising re-arranged heavy andlight chains produced from said mutated loci hasbeen substantially reduced or eliminated.
