The present invention provides a synergistic herbicidal composition comprising pyroxasulfone, mesotrione and atrazine as the active components, wherein the weight ratio of pyroxasulfone, mesotrione and atrazine ranges from 1 to 10:1 to 50:1 to 100, as well as the use of the synergistic herbicidal composition of present invention for controlling the growth of undesirable plants. The present invention also provides a method of controlling the growth of undesirable plants, which comprises applying the active components pyroxasulfone, mesotrione and atrazine of the synergistic herbicidal composition of present invention to the undesirable plants or their growing locus jointly or separately. The present invention further provides a method of reducing or preventing harm caused by pyroxasulfone when applied to plants, seeds or other reproductive parts of useful crops.本發明提供一種協同性除草組合物,包含活性組分派羅克殺草碸、硝磺草酮和草脫淨,其中派羅克殺草碸、硝磺草酮、草脫淨的重量配比範圍是1~10:1~50:1~100本發明的協同性除草組合物用於防治不希望的植物生長中的用途。本發明還提供一種防治不希望的植物生長的方法,將本發明的協同性除草組合物的活性組分派羅克殺草碸、硝磺草酮和草脫淨共同或單獨地施用於不希望的植物或其生長場所。本發明還提供一種降低或防止派羅克殺草碸對用其處理的有用作物的植株、有用作物的種子或有用作物的其他繁殖部分所造成的損害的方法。