A synergistic herbicidal composition comprising pyroxasulfone, mesotrione and atrazine as the active components is provided, wherein the weight ratio of pyroxasulfone, mesotrione and atrazine ranges from 1 to 10:1 to 50:1 to 100. The use of the synergistic herbicidal composition for controlling the growth of undesirable plants is also provided. The present invention also provides a method of controlling the growth of undesirable plants, which comprises applying the active components pyroxasulfone, mesotrione and atrazine of the synergistic herbicidal composition to the undesirable plants or their growing locus jointly or separately. A method of reducing or preventing harm caused by pyroxasulfone when applied to plants, seeds or other reproductive parts of useful crops is further provided.
