LONG, LI,LUQMAN, MOHAMMAD,YABANNAVAR, ASHA,ZAROR, ISABEL,CHEN, BAO-LU,LU, XIAOFENG,LEE, SANG HOON,HURST, DEBORAH
申请号：
CA2544949
公开号：
CA2544949C
申请日:
2004.11.04
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Methods of therapy for treating diseases mediated by stimulation of CD40signaling on CD40-expressing cells are provided. The methods compriseadministering a therapeutically effective amount of an antagonist anti-CD40antibody or antigen-binding fragment thereof to a patient in need thereof. Theantagonist anti-CD40 antibody or antigen-binding fragment thereof is free ofsignificant agonist activity, but exhibits antagonist activity when theantibody binds a CD40 antigen on a human CD40-expressing cell. Antagonistactivity of the anti-CD40 antibody or antigen-binding fragment thereofbeneficially inhibits proliferation and/or differentiation of humanCD40~expressing cells, such as B cells.
