Sang Hoon Lee;Deborah Hurst;Isabel Zaror;Mohammad Luqman;Xiaofeng Lu;Asha Yabannavar;Li Long;Bao-Lu Chen
发明人:
Li Long,Mohammad Luqman,Asha Yabannavar,Isabel Zaror,Bao-Lu Chen,Xiaofeng Lu,Sang Hoon Lee,Deborah Hurst
申请号：
US11932472
公开号：
US08277810B2
申请日:
2007.10.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
