LONG, LI,LUQMAN, MOHAMMED,YABANNAVAR, ASHA,ZAROR, ISABEL,CHEN, BAO-LU,LU, XIAOFENG,LEE, SANG HOON,HURST, DEBORAH
申请号：
PL09075395
公开号：
PL2149585T3
申请日:
2004.11.04
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
