Jenkins, Thomas E.,Husfeld, Craig O.,Seroogy, Julie D.,Wray, Jonathan W.
申请号：
AU2010351605
公开号：
AU2010351605C1
申请日:
2010.04.21
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.
