Thomas E. Jenkins,Craig O. Husfeld,Julie D. Seroogy,Jonathan W. Wray
申请号:
US13686725
公开号:
US09040032B2
申请日:
2012.11.27
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an opioid prodrug that provides enzymatically-controlled release of an opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the opioid from the opioid prodrug so as to attenuate enzymatic cleavage of the opioid prodrug.