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New galectin galactoside inhibitors
专利权人:
Galecto Biotech AB
发明人:
LEFFLER, Hakon,NILSSON, Ulf J.,VON WACHENFELDT, Henrik
申请号:
ES10770027
公开号:
ES2652488T3
申请日:
2010.04.26
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of general formula (I): ** (See formula) ** wherein the pyranose ring configuration is D-galacto; X is selected from the group consisting of O and S; Y and Z are selected from a 1H-1,2,3-triazole ring; R1 and R2 are independently selected from the group consisting of: a) an alkyl group of at least 4 carbons, an alkenyl group of at least 4 carbons, an alkynyl group of at least 4 carbons; b) a carbamoyl group, a carbamoyl group substituted with an alkyl group, a carbamoyl group substituted with an alkenyl group, a carbamoyl group substituted with an alkynyl group, a carbamoyl group substituted with an aryl group, a carbamoyl group substituted with an alkyl group substituted, and a carbamoyl group substituted with a substituted aryl group; c) a phenyl group substituted with at least one carboxy group, a phenyl group substituted with at least one halogen, a phenyl group substituted with at least one alkyl group, a phenyl group substituted with at least one alkoxy group, a phenyl group substituted with at least one trifluoromethyl group, a phenyl group substituted with at least one trifluoromethoxy group, a phenyl group substituted with at least one sulfo group, a phenyl group substituted with at least one hydroxy group, a phenyl group substituted with at least one carbonyl group, and a phenyl group substituted with at least one substituted carbonyl group; d) a naphthyl group, a naphthyl group substituted with at least one carboxy group, a naphthyl group substituted with at least one halogen, a naphthyl group substituted with at least one alkyl group, a naphthyl group substituted with at least one alkoxy group, a naphthyl group substituted with at least one sulfo group, a naphthyl group substituted with at least one hydroxyl group, a naphthyl group substituted with at least one carbonyl group and a naphthyl group substituted with at least one substituted carbonyl group; e) a heteroaryl group, a heteroaryl group substituted with at least one carboxy group, a he
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