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不安神経症又はうつ症治療薬、及びピペラジン誘導体
专利权人:
大正製薬株式会社
发明人:
中里 篤郎,茶木 茂之,大久保 武利,小川 伸一,石井 孝明
申请号:
JP2002505040
公开号:
JP5002881B2
申请日:
2001.06.27
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
There are provided a therapeutic preparation for anxiety neurosis or depression which comprises a MC4 receptor antagonist as an effective ingredient and a piperazine derivative represented by Formula Ä1Ü: Äwherein Ar<1> is a phenyl group, a substituted phenyl group, a naphthyl group or a substituted naphthyl group Ar<2> is a naphthyl group, a substituted naphthyl group, a quinolyl group, a group represented by the formula: (wherein R<4> is a hydrogen atom or a halogen atom and X-Y is CH-NH, CH-O, CH-S or N-O) or a group represented by the formula: (wherein R<5> is a hydrogen atom, a hydroxyl group or a C1-10 alkoxy group) R<1> is a hydrogen atom, a C1-10 alkyl group, a C3-8 cycloalkyl group, a C3-10 alkenyl group, a phenyl group, a 1-cyanoethyl group, a pyrimidin-2-yl group or an amidyl group R<2> and R<3> are the same or different, and are each a hydrogen atom or a C1-10 alkyl group A-B is N-CH2, CH-CH2, C(OH)-CH2 or C=CH T<1> is a single bond, -N(R<6>)- (wherein R<6> is a hydrogen atom or a C1-10 alkyl group), -O-, -CH=CH- or -C(=O)- n is an integer of from 1 to 10 and when T<1> is a single bond, -CH=CH- or -C(=O)-, n is an integer of from 2 to 10 when T<1> is -N(R<6>)- or -O-Ü, or a pharmaceutically acceptable salt thereof.
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来源网址:
http://www.ckcest.cn/home/
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