The present invention provides compound, pharmaceutical composition, inhibits ROR gamma activities in subject and/or reduce the method for IL-17 amounts and the method using these compounds and the various medical conditions of medicine composite for curing.本發明提供化合物、藥物組合物、在受試者中抑制RORγ活性及/或降低IL‑17量的方法、及使用這些化合物和藥物組合物治療各種醫學病症的方法。