What octahydro-pyrrolo- [3,4-b] azole derivatives are closed in system of the present invention, and available what treatment is prevented by histamine-3-receptor ligand or improved illness or symptom. Octahydro-pyrrolo- [3,4-b] azole compounds disclosed herein use the method for the method of the compounds such as this, the composition for the compounds such as prepare this and the compounds such as prepare this.本發明係關於八氫-吡咯并[3,4-b]吡咯衍生物,其可用於治療由組胺-3受體配體預防或改善之病症或病狀。本文揭示八氫-吡咯并[3,4-b]吡咯化合物、使用該等化合物之方法、製備該等化合物之組合物及製備該等化合物之方法。