Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent； and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.本發明提供一種治療個體之細胞增生病症之方法，其包括：(1)將至少一種當經活化時能實現預定細胞變化之可活化醫藥試劑投與該個體，其可單獨投藥或與至少一種能量調節劑組合之形式投藥，及(2)將來自一引發能源之引發能施加於該個體，其中該施加法即就地活化該可活化試劑，由此發生該預定細胞變化，其中該預定細胞變化較佳藉由增加或減小細胞增生速率來治療該細胞增生病症；及進行該方法之套組、進行該方法之電腦實施系統、適用於該方法之醫藥組合物及使用該方法在個體體內引起自體疫苗效應之方法。
