PROBLEM TO BE SOLVED: To provide an excellent overactive bladder remedy evaluation model.SOLUTION: A method for evaluating overactive bladder remedies includes a step (1) for inducing spontaneous shrinkage increase of an extracted bladder by treating the extracted bladder with α1 adrenalin receptor agonist and M3 muscarine receptor agonist a step (2) for treating the extracted bladder with a test drug a step (3) for measuring spontaneous shrinkage increase when the extracted bladder is treated with the test drug and comparing the measured result with spontaneous shrinkage of the extracted bladder when the extracted bladder is not treated with the test drug and a step (4) for identifying or selecting a test drug having a function capable of suppressing the spontaneous shrinkage increase of the extracted bladder as an overactive bladder remedy.COPYRIGHT: (C)2013,JPO&INPIT【課題】優れた過活動膀胱治療薬の評価モデルを提供する。【解決手段】以下の工程を含む過活動膀胱治療薬の評価方法。1)α1アドレナリン受容体アゴニストおよびM3ムスカリン受容体アゴニストで処理することにより、摘出膀胱の自発性収縮増大を誘導する工程2)被験薬剤で摘出膀胱を処置する工程3)被験薬剤で摘出膀胱を処置した際の自発性収縮増大を測定し、処置しなかった際の摘出膀胱の自発性収縮と比較する工程4)摘出膀胱の自発性収縮増大を抑制する作用を有する被験薬剤を過活動膀胱治療薬として認定又は選出する工程【選択図】図1
