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Fumarate Salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, Methods of Preparation, and Uses Thereof
专利权人:
Helsinn Healthcare SA
发明人:
Silvina GARCIA RUBIO,Mauro PERSEGHINI,Angelo GUAINAZZI,Claudio PIETRA,Claudio GIULIANO
申请号:
US16767842
公开号:
US20200299260A1
申请日:
2018.12.07
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided are various embodiments relating to fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl)urea, and methods of producing and using the same to treat conditions and disorders associated with an increase of ghrelin level, such as food abuse, alcohol addiction, and other disorders (e.g., Prader-Willi syndrome). Also provided are various embodiments relating to crystalline HM04 free base, different crystalline forms of HM04 fumarate salt, and methods of producing the same.
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