Maiti Samarendra N.,Nguyen Dai,Khan Jehangir,Ling Rong
申请号：
NZ70935512
公开号：
NZ709355A
申请日:
2012.12.11
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Microbial drug resistance is an unavoidable consequence resulting from abuse and overuse of antimicrobial agents. Given the degree of popularity of β-lactam antibiotics, it is not surprising that the prevalence of β-lactamase-producing strains is increasing worldwide. β-lactamases are able to hydrolyze the β-lactam antibiotics resulting in the loss of antibacterial activity. The present invention addresses this problem by providing compounds that inhibit some of the β-lactamase enzymatic function either alone or in synergy with other β-lactam antibiotics, increasing the potency of β-lactam antibiotics. In particular, the present invention provides a compound of formula (I) wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation Y is OR1 or NR2R3, and R1, R2, R3 and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds are disclosed.
