The purpose of the present invention is to provide a drug that demonstrates a pharmaceutical effect by having high mobility to the mid-brain and converting to bumetanide in the mid-brain, which is the primary site of epilepsy. The present invention provides a sulfamoylbenzene derivative expressed by general formula (1), or a pharmacologically permissible salt thereof.本發明之目的為提供一種朝向腦中之移行性高,在癲癇之發病部位即腦中可轉變為布美他尼(bumetanide),而發揮藥理效果之醫藥。本發明係提供下述通式(I)所示之胺磺醯基苯衍生物或其藥學上可容許之鹽:
