Christian Klein,Erhard Kopetzki,Harald Duerr,Joerg Thomas Regula,Juergen Michael Schanzer,Katharina Wartha,Pablo Umana,Rebecca Croasdale,Ulrich Brinkmann,Wilma Lau
申请号：
BR112012024312
公开号：
BR112012024312A2
申请日:
2011.03.24
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
Biespec\u00edficos Antibodies, Methods for their production, Pharmaceutical compositions for the treatment of cancer containing such Antibodies, and Uses Thereof. Nucleic Acid Molecule expression vector, host cell.Claim 1 which comprises: a) biespec\u00edfico Antibody heavy chain and light chain of a First full length Antibody that specifically binds to an Antigen (b) the heavy chain and light chain of a Second Antibody that binds specific full length Only a Second AntigenThe n terminus of the heavy chain is connected with the C terminus of the light chain by a peptide binding. The Antibody biespec\u00edfico claim 7: According to claim 1, characterized in that a) The First full length Antibody binds specifically to igf-1r and comprises a heavy chain with the amino acid sequence of id.SEC. 1 ns, and a light chain with the amino acid sequence of id. sec. No 2: and (b) the second full length Antibody binds specifically to EGFR and comprises a heavy chain connected to the light chain by a peptide binding in the Light And Heavy Chains connected by Peptide with the amino acid sequence of id. sec. No 3.Claim 1: The Antibody biespec\u00edfico according to claim 1, characterized in that a) The First full length Antibody specifically binds to VEGF and comprises a heavy chain with the amino acid sequence of id. sec. 9 NS, and a light chain with the amino acid sequence of id. sec.Ns 10, and (b) the second full length Antibody binds specifically to ang - 2 and comprises a heavy chain connected with the light chain by a peptide binding in the Light And Heavy Chains connected by Peptide with the amino acid sequence of id. sec. 11 NS.Anticuerpos biespecíficos, métodos para su produccion, composiciones farmacéuticas para el tratamiento del cáncer que contienen dichos anticuerpos, y usos de los mismos. Vector de expresion molécula de acido nucleico, célula huésped. Reivindicacion 1: Un anticuerpo biespecífico que comprende a) la cadena ligera y la cadena pesada de un primer anticuerp
