UNIVERSITE MONTPELLIER I;CENTRE NATIONAL DE LUTTE CONTRE LE CANCER;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);LFB BIOTECHNOLOGIES
发明人:
BEHRENS, CHRISTIAN
申请号：
ARP110101115
公开号：
AR081159A1
申请日:
2011.04.01
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
The second type of anti wool hormone receptor is 12 G4 mutant antibody and its fragments. Nucleic acids, vectors, host cells and pharmaceutical ingredients that contain them. 1. Claim 1: a single human clone antibody composed of 12 G4, including or composed of the following components: (a) a light chain composed of or composed of the following components: a variable region, wherein the amino acid sequence is represented by SEQ ID NS 2 or SEQ ID ns 4, And a constant region, the amino acid sequence is represented by SEQ ID ns 6 or a sequence, which shows at least 80% homology with SEQ ID ns 6；(b) A heavy chain consisting of a variable region in which the amino acid sequence is represented by SEQ ID ns 8 or SEQ ID ns 10, In a constant region, the amino acid sequence is represented by SEQ ID ns 12 or a sequence, which has at least 80% homogeneity with SEQ ID ns 12； the sequence has a single human clone antibody mutation of 12 G4, at least one light and / or heavy chain mutation,And provide a Kuwait Dinar for the second kind of human amhrii receptor, at least equivalent to the Kuwait Dinar of the monomer chemical 12g4 antibody receptor, the receptor includes or includes: a variable region, wherein the amino acid sequence is represented by SEQ ID ns 14； a constant region, wherein the amino acid sequence is represented by it It is represented by SEQ ID ns 6, (b) a heavy chain composed of: a variable region, in which the amino acid sequence is represented by SEQ ID ns 18 or SEQ ID ns 10； a continuous region, in which the amino acid sequence is represented by SEQ ID ns 12, for the receiver, it is better to be less than 10-7m,Especially under 10-8m, especially between 10-9m and 10-11m.Anticuerpos humanizados 12G4 mutados, y sus fragmentos, dirigidos contra el receptor de la hormona anti-mulleriana de tipo II. Acido nucleico, vector, célula hospedante y composición farmacéutica que lo contiene. Reivindicación 1: Anticuerpo monoclonal humanizado 12G4 que comprende o está consti
