It also provides a Vector comprising Said DNA, a host Cell, a transgenic animal and a composition comprising the disclosed c-met Antibody and its use as a Medicine to treat cancer.Claim 1: a monoclonal antibody or Functional fragment or divalent derivative capable of inhibiting c-met dimerization, comprising a Chain comprising Said Antibody was cor - H1, H2 and H3 Cor Cor respectively with the amino acid sequences SEC ID 1, 2 and 3； and To light chain comprising cor - L1CDR CdR L2 and L3 respectively - with the amino acid sequences SEC ID 5, 6 and 7 were additionally characterized because the Antibody also comprises a Hinge region that comprises the Amino Acid Sequence SEC ID NS: 56.Isolated nucleic acid: a claim 15, wherein the Nucleic Acid is selected from the following: (a) a Nucleic Acid, DNA or RNA, which encodes an Antibody or fragment or derivative Functional divalent, as claimed in one of claims 1 to 14； (b) a Nucleic Acid comprising a DNA Sequence comprising sequences SEC ID no: 11HL: 12 sec SEC ID, id: 13 NS and 15 NS: ID sequences SEC, SEC and sec id ID Ns, 16 NS: 17； (c) a Nucleic Acid comprising a DNA Sequence comprising sequences SEC and sec id id NS: NS 14: 1819 or 20； (d) the corresponding Nucleic Acids RNA Nucleic Acids as defined in (b) or (c)； (e) the complementary Nucleic Acids Nucleic Acids as defined in (a), (b) and (c)； (f) a Nucleic Acid of at least 18 nucleotides able to hybridize under condi In high Severity with at least one of the CDRs Sequence sec id: 11 to 13 and 15 to 17.Винахід належить до застосування моноклонального антитіла або його бівалентного функціонального фрагмента, здатного інгібувати димеризацію c-Met, та застосування композиції, що містить моноклональне антитіло або його бівалентний функціональний фрагмент, які здатні інгібувати димеризацію c-Met для застосування при попередженні та/або лікуванні раку, що характеризується гіперекспресією c-Met, яка є результатом генної ампліфікації c-Met, такого як рак ШКТ або нирково-кліт
